abstract：:The 36-amino-acid peptide, neuropeptide Y (NPY), is the most abundant peptide in the rat brain. When administered into the brain, NPY produces a variety of physiological actions including a pronounced stimulation of feeding in satiated rats. Elevations in hypothalamic NPY have been reported after food deprivation and ...

journal_title：Neuropeptides

authors： Gehlert DR

更新日期：1999-10-01 00:00:00

abstract：:Procolipase is secreted as a protein consisting of 101 amino acids. In the intestinal lumen, procolipase is activated by trypsin and cleaves to form the active colipase and the pentapeptide from the amino terminus. This pentapeptide is called enterostatin. Pancreatic procolipase synthesis is stimulated by a high-fat d...

journal_title：Neuropeptides

authors： Liu M,Shen L,Tso P

更新日期：1999-10-01 00:00:00

abstract：:Neuropeptide Y (NPY) -receptor subtypes were studied in the rat kidney in vivo by systemic administration of NPY, the two agonists [Leu(31), Pro(34)]NPY (Y1-receptor agonist) and NPY (13-36) (Y2-receptor agonist), or the Y1-receptor antagonist BIBP 3226. Effects on mean arterial blood pressure (MAP) and renal arterial...

journal_title：Neuropeptides

authors： Modin A,Malmström RE,Meister B

更新日期：1999-08-01 00:00:00

abstract：:Specific antagonists were used to determine NK1 and NK2 receptor mediation of the expression of c-Jun and c-Fos inducible transcription factors. (ITFs) in dorsal horn neurons. The induction of c-Jun by C-fiber stimulation was strongly reduced in the superficial laminae by NK1 and NK2 antagonists, but only weakly in th...

journal_title：Neuropeptides

authors： Redburn JL,Leah JD

更新日期：1999-04-01 00:00:00

abstract：:The pathophysiological basis for the pain of migraine has been the subject of substantial attention and must include activation of elements of the trigeminal innervation of the cranial vessels, the trigeminovascular system. Recently, consideration of trigeminal-evoked neurogenic plasma protein extravasation (PPE) as a...

journal_title：Neuropeptides

authors： Knight YE,Edvinsson L,Goadsby PJ

更新日期：1999-02-01 00:00:00

abstract：:Pituitary adenylate cyclase activating peptide and vasoactive intestinal peptide belong to the same neuropeptide family. Both peptides are present in nerve fibers in the gastric wall and are thought to be involved in the regulation of inflammatory processes. Experimental ulcers were induced in the rat gastric mucosa b...

journal_title：Neuropeptides

authors： Mei Q,Sundler F

更新日期：1998-12-01 00:00:00

abstract：:The antinociceptive effect of intrathecally (i.t.) administered protease inhibitors was tested against capsaicin (800 ng) injected into the dorsal surface of a hindpaw. Both p-hydroxymercuribenzoate (2-8 nmol), a cysteine protease inhibitor, and phosphoramidon (1-4 nmol), an endopeptidase 24.11 inhibitor in the presen...

journal_title：Neuropeptides

authors： Tan-No K,Taira A,Inoue M,Ohshima K,Sakurada T,Sakurada C,Nylander I,Demuth HU,Silberring J,Terenius L,Tadano T,Kisara K

更新日期：1998-10-01 00:00:00

abstract：:Striatal neuropeptide Y-like immunoreactivity (NPY-LI) levels were investigated in naive rats after acute, subchronic (14 days) or chronic (28 days) intraperitoneal (i.p.) treatment with chlorpromazine (2 or 10mg/kg), haloperidol (0.5 or 2 mg/kg), (+/-)sulpiride (50 or 100 mg/kg) or clozapine (10 or 25 mg/kg), and in ...

journal_title：Neuropeptides

authors： Obuchowicz E,Turchan J

更新日期：1998-10-01 00:00:00

abstract：:Proenkephalin peptides produced by endocrine and nervous tissues are involved in stress-induced immunosuppression. However, the role of peptides produced by immune cells remains unknown. The present study examines the effect of acute and chronic foot-shock stress on proenkephalin peptide content in bone marrow (BMMC),...

journal_title：Neuropeptides

authors： Saravia F,Padros MR,Ase A,Aloyz R,Duran S,Vindrola O

更新日期：1998-08-01 00:00:00

abstract：:Peripheral neurons begin to express galanin after axotomy. When neurons in the superior cervical ganglion were axotomized near (about 2 mm) from the ganglion, galanin-like immunoreactivity (IR) was maximal within 72 h. Axotomy of neurons in the middle and inferior cervical ganglion complex (MICG), which could be perfo...

journal_title：Neuropeptides

authors： Shadiack AM,Zigmond RE

更新日期：1998-06-01 00:00:00

abstract：:The present study was undertaken in order to establish the possible involvement of melatonin in the mechanisms underlying the arginine-vasopressin (AVP) responses to physical exercise and angiotensin II (ANG II). On two mornings at least 1 week apart, normal male subjects were tested with exercise on a bicycle ergomet...

journal_title：Neuropeptides

authors： Chiodera P,Volpi R,Capretti L,Giuliani N,Maffei ML,Coiro V

更新日期：1998-04-01 00:00:00

abstract：:In rat preprogalanin, galanin is C-terminally flanked by a 60 amino acid long peptide: galanin message-associated peptide (GMAP). GMAP sequences in different species show high degree of homology, suggesting a biological role. However, the study of the physiological and pharmacological actions of this peptide have been...

journal_title：Neuropeptides

authors： Andell-Jonsson S,Bartfai T

更新日期：1998-04-01 00:00:00

abstract：:This study found that dynorphin had a biphasic concentration response relationship on N-methyl-D-aspartate (NMDA) receptor-mediated currents in the CA3 region of the guinea pig hippocampal slice. A previous study demonstrated that the inhibitory effect was mediated by a kappa 2 opioid receptor. In the present study, t...

journal_title：Neuropeptides

authors： Caudle RM,Dubner R

更新日期：1998-02-01 00:00:00

abstract：:We examined the effects of gestational cocaine treatment on oxytocin levels in the whole hippocampus (HIP), ventral tegmental area (VTA), medial preoptic area (MPOA) and amygdala (AMY) in rat dams on postpartum days (PPDs) 1 and 2. Cocaine treatment significantly reduced oxytocin levels in the MPOA within 12-16 h of d...

journal_title：Neuropeptides

authors： Johns JM,Lubin DA,Walker CH,Meter KE,Mason GA

更新日期：1997-10-01 00:00:00

abstract：:The aim of the present investigation was to determine if chronic activation of kappa-opioid receptor induces development of tolerance and dependence to kappa-opioid agonists on the isolated right atrium of the rat. Tolerance to the kappa-agonist was induced by chronic administration of U-50,488H, a selective kappa-ago...

journal_title：Neuropeptides

authors： Milanés MV,Rabadan JV,Laorden ML

更新日期：1997-10-01 00:00:00

abstract：:Perivascular sensory nerves release calcitonin gene-related peptide (CGRP) and substance P, the dilator actions of which can be regulated by nitric oxide (NO). This study investigated the role of NO in the vasodilation caused by sensory nerve stimulation, by capsaicin, or exogenous CGRP and substance P in the isolated...

journal_title：Neuropeptides

authors： Mitchell JA,Williams FM,Williams TJ,Larkin SW

更新日期：1997-08-01 00:00:00

abstract：:Melanin-concentrating hormone (MCH) and dynorphin genes are expressed in two discrete neuron populations of the rat lateral hypothalamus. Their roles remain hypothetical in mammals. In order to analyse changes in MCH and dynorphin gene expression, a multiplex competitive semi-quantitative reverse transcription-polymer...

journal_title：Neuropeptides

authors： Hervé C,Fellmann D

更新日期：1997-06-01 00:00:00

abstract：:Bombesin (BN) and its mammalian counterpart gastrin-releasing peptide act as neuroregulatory hormones and tissue-specific growth factors, and have been implicated as peripheral and central satiety-inducing agents. In the present study, the immunohistochemical expression of BN in submandibular, sublingual and parotid g...

journal_title：Neuropeptides

authors： Aalto Y,Kjörell U,Henriksson R,Franzén L,Forsgren S

更新日期：1997-04-01 00:00:00

abstract：:We studied head-injured patients assessed after admission to the hospital according to the Glasgow coma scale (3-8 points). All of them underwent surgical procedure after neuroradiological examination. Due to therapeutic problems, some of these patients had lumbar puncture on the fourth day following surgery. The cont...

journal_title：Neuropeptides

authors： Stachura Z,Obuchowicz E,Herman ZS

更新日期：1997-02-01 00:00:00

abstract：:Plasma protein extravasation in the upper airways of anesthetized guinea pigs was measured with the FITC (Fluorescein isothiocyanate)-dextran technique. The effect of selective tachykinin (NK1 and NK2) receptor agonists and antagonists, capsaicin or antigen was studied. The tachykinin NK1 receptor agonist, [Sar9]subst...

journal_title：Neuropeptides

authors： Evangelista S,Paoli S,Giachetti A,Manzini S

更新日期：1997-02-01 00:00:00

abstract：:Cholecystokinin-B (CCK-8) is an octapeptide that was initially described in the gastrointestinal tract. Recent studies have shown that this peptide also has an extensive distribution in the central nervous system, including the cerebellum of the opossum. In addition to the protein, binding sites for CCK-8 also have be...

journal_title：Neuropeptides

authors： Bishop GA

更新日期：1996-12-01 00:00:00

abstract：:The present study was undertaken to determine whether neurotensin is involved in the regulation of the intestinal postprandial motor response and, if so, whether the regulatory pathway depends upon peripheral or central neurotensin secretion. Neurotensin, injected by the i.v. route (5 micrograms/kg) during the fasting...

journal_title：Neuropeptides

authors： Pellissier S,Eribon O,Chabert J,Gully D,Roche M

更新日期：1996-10-01 00:00:00

abstract：:Male Wistar rats were injected intraperitoneally with chlorpromazine (2 or 10 mg/kg), haloperidol (0.5 or 2 mg/kg), sulpiride (50 or 100 mg/kg) or clozapine (10 or 25 mg/kg) once, for 14 or 28 consecutive days. Hypothalamic neuropeptide Y-like (NPY-like) immunoreactivity (NPY-LI) was determined 24 h after the last dos...

journal_title：Neuropeptides

authors： Obuchowicz E

更新日期：1996-10-01 00:00:00

abstract：:The effect of the selective non-peptide antagonist for NK1 receptors (+/-)CP 96,345 on cellular transduction mechanisms elicited by the NK1 selective agonist [Sar9]-substance P-sulfone ([Sar9]-SP) was investigated in a stabilized culture of human skin fibroblasts (HF) and compared to the effects of two peptide antagon...

journal_title：Neuropeptides

authors： Ziche M,Parenti A,Amerini S,Zawieja D,Maggi CA,Ledda F

更新日期：1996-08-01 00:00:00

abstract：:The distribution of beta-endorphin (1-27) immunoreactive cell bodies and fibres was studied in the diencephalon of the cat using an indirect immunoperoxidase technique. In the thalamus, almost all the immunoreactive fibres were found in the midline region and in nuclei located near the midline, whereas in the hypothal...

journal_title：Neuropeptides

authors： Coveñas R,de León M,Narváez JA,Tramu G,Aguirre JA,González-Barón S

更新日期：1996-06-01 00:00:00

abstract：:The effects of forskolin or phorbol-13-myristate (PMA) injected intrathecally (i.t.) or intracerebroventricularly (i.c.v.) on the inhibition of the tail-flick and hotplate responses induced by morphine or beta-endorphin administered i.c.v. were studied. Animals pretreated with forskolin (20 micrograms) i.t. for 10 min...

journal_title：Neuropeptides

authors： Suh HW,Song DK,Sim YB,Chung KM,Kim YH

更新日期：1996-04-01 00:00:00

abstract：:Immunohistochemical tests have demonstrated for the first time the presence of endothelins in the neuroendocrine cells of fish gill. We have sought co-localization of endothelins with serotonin and neuropeptides which are regarded as neuroendocrine markers of pulmonary diffuse neuroendocrine systems in higher vertebra...

journal_title：Neuropeptides

authors： Zaccone G,Mauceri A,Fasulo S,Ainis L,Lo Cascio P,Ricca MB

更新日期：1996-02-01 00:00:00

abstract：:Using canine spleen and lung membranes as model systems, we have shown the presence of subtypes of ETB receptors. This classification was done based on the binding profiles of various analogs of ET-1 that have been identified as ETB-selective. Saturation binding experiments performed with [125I] ET-3 and [125I] IRL-12...

journal_title：Neuropeptides

authors： Nambi P,Pullen M,Brooks DP,Gellai M

更新日期：1995-12-01 00:00:00

abstract：:We investigated the effect of sulphated cholecystokinin octapeptide (CCK-8S) on free intracellular calcium concentration, phosphatidylinositol metabolism, and protein phosphorylation in C6 cells, a rat glioma cell line which was shown to express CCKB type receptors. Increase in [Ca2+]i by both influx across the cell m...

journal_title：Neuropeptides

authors： Kaufmann R,Schöneberg T,Lindschau C,Haller H,Ott T

更新日期：1995-11-01 00:00:00

abstract：:Regulation of cholecystokinin (CCK) expression was studied in the human neuroepithelioma cell line SK-N-MCIXC and the rat medullary thyroid carcinoma cell line WE 4/2. The cells were treated with the beta-adrenergic agonist isoproterenol and retinoic acid, a natural derivative of vitamin A, which plays a role in cell ...

journal_title：Neuropeptides

authors： Mania-Farnell BL,Botros IW,Davis TP

更新日期：1995-10-01 00:00:00

abstract：:Oxytocin, intraperitoneally injected to 26-month-old male rats 60 min before testing, significantly improved social memory (at doses of 3 and 6 ng/kg) and reduced the duration of immobility in the behavioral despair test (at doses of 50 and 500 micrograms/kg). These results are in agreement with previous data obtained...

journal_title：Neuropeptides

authors： Arletti R,Benelli A,Poggioli R,Luppi P,Menozzi B,Bertolini A

更新日期：1995-09-01 00:00:00

abstract：:Pyroglutamyl peptidase I activity from soluble and membrane-bound fractions of rat brain homogenates is inhibited by the presence of sodium deoxycholate but not by triton X-100. Biobeads SM2, a polystyrene adsorbent reported to be useful in removing detergents from aqueous solutions, inhibits enzymatic activity in bot...

journal_title：Neuropeptides

authors： Alba F,Arenas JC,Lopez MA

更新日期：1995-08-01 00:00:00

abstract：:The effects of stimulation and blockade of neurotensin receptors on striatal acetylcholine release were examined in anaesthetized rats using microdialysis. Local perfusion with neurotensin (100 nM) did not influence the release of acetylcholine. Application of neurotensin (100 nM) 30 min after haloperidol (125 microgr...

journal_title：Neuropeptides

authors： Steinberg R,Rodier D,Mons G,Gully D,Le Fur G,Soubrié P

更新日期：1995-07-01 00:00:00

abstract：:Neurokinin A (NKA) and substance P (SP) are often co-localized in small sensory neurons and have been suggested to subserve similar roles. We have now compared tissue levels of NKA and SP in rat cervical dorsal root ganglia with those in the central and peripheral terminations of the same neurons. We found that NKA co...

journal_title：Neuropeptides

authors： Bakhle YS,Bell C

更新日期：1995-04-01 00:00:00

abstract：:Available data concerning the effect of oxytocin on memory are often inconsistent. In the present study it was found that oxytocin, intracerebroventricularly injected to adult male rats in a dose range of 1 fg-10 ng/rat immediately after a 5-minute encounter with a juvenile, significantly reduces the social investigat...

journal_title：Neuropeptides

authors： Benelli A,Bertolini A,Poggioli R,Menozzi B,Basaglia R,Arletti R

更新日期：1995-04-01 00:00:00

abstract：:The relative roles of hypothalamic corticotropin-releasing-hormone (CRH) and vasopressin (AVP) as mediators of the stimulant effect of vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI) on ACTH and corticosterone (CORT) secretion, were examined using receptor blockade of endogenous CRH and AVP....

journal_title：Neuropeptides

authors： Alexander LD,Sander LD

更新日期：1995-03-01 00:00:00

abstract：:The effects of the GABAergic drugs nipecotic acid, Gabrene, baclofen and metatolylcarbamide (MTC), when given alone or in combination at subthreshold doses with AT II also at a subthreshold dose effective on PTZ-kindling in mice were studied. PTZ-kindling was provoked by intraperitoneal (i.p.) injections of PTZ (40 mg...

journal_title：Neuropeptides

authors： Georgiev VP,Lazarova MB,Kambourova TS

更新日期：1995-01-01 00:00:00

abstract：:We have measured cerebrospinal fluid (CSF) neuropeptide Y-like immunoreactivity (NPY-LI) and somatostatin-like immunoreactivity (SLI) in control subjects and in patients with various neurologic disorders. We observed a significant reduction in CSF SLI in control subjects over 60 years of age, compared with the younger...

journal_title：Neuropeptides

authors： Maeda K,Yasuda M,Kaneda H,Maeda S,Yamadori A

更新日期：1994-12-01 00:00:00

abstract：:The distributions of four prodynorphin-derived peptides, dynorphin A (1-17), dynorphin A (1-8), dynorphin B, and alpha-neo-endorphin were determined in 10 cortical regions and the striatum of the old world monkey (Macaca nemestrina). alpha-neo-endorphin was the most abundant peptide in both cortex and striatum. The co...

journal_title：Neuropeptides

authors： Healy DJ,Meador-Woodruff JH

更新日期：1994-11-01 00:00:00

abstract：:We have recently documented the expression of preprothyrotropin-releasing hormone (TRH) gene in murine, human and rat testis. Moreover, we have localized TRH to rat Leydig cells immunohistochemically, and found that both prepro TRH mRNA and TRH levels are developmentally regulated in the rat testis. To investigate the...

journal_title：Neuropeptides

authors： Satoh T,Feng P,Kim UJ,Wilber JF

更新日期：1994-09-01 00:00:00